RA DIOP H A RMACY TEC-CONTROL™ CHROMATOGRAPHY SYSTEMS For radiopharmaceutical quality control TEC-CONTROL™ ALUMINUM BREAKTHRU KIT Simple 3-step procedure T he Aluminum Breakthru Kit provides a rapid, easy and inexpensive way to test aqueous solutions, particularly pertechnetate generator eluate, for trace quantities of aluminum. Aluminum forms an intense red precipitate with the indicator paper, and the intensity of the color is directly proportional to the amount of aluminum in the solution. The USP allows a concentration of aluminum ion in an injection ≤ 10 micrograms per milliliter (10 µg/ml) in technetium 99m eluate prepared from Molybdenum 99 formed as a result of uranium fission. Simple Procedure: 1. Place a drop of the eluate or solution to be tested on the indicator paper. The best procedure is to form a hanging drop using a 19-22G needle. 2. Place a drop of the standard aluminum solution on the indicator paper. Use the same size drop. 3. Compare the intensity of the red spot formed. If the eluate spot is less intense than the standard solution, the eluate contains less than 10µg/ml aluminum. 150-780 T ec-Control™ Chromatography tests the radiochemical purity of specific Tc-99m-labeled radiopharmaceuticals. The accompanying chart shows which strips and solvents are required to perform each individual test. Some solvents must be purchased separately (see Sigma-Aldrich chart) due to hazardous material shipping restrictions. Detailed instruction manuals are packaged with each strip container, although our Radiopharmaceutical QC Procedure Manual (150-000) explains paper chromatography in greater detail. Radiopharmaceutical QC Manual MINIATURIZED CHROMATOGRAPHY PROCEDURES FOR RADIOPHARMACEUTICALS: 2011 UPDATE 150-000 BY A. MICHAEL ZIMMER, PhD T 150-785 Chromatography Kit, Tec-Control Aluminum Breakthru Kit includes: Aluminum standard, 5 ml, 10 ug/ml, 50 indicator strips and manual Chromatography Kit, Tec-Control Aluminum Breakthru Kit includes: Aluminum standard, 5 ml, 5 ug/ml, 50 indicator strips and manual References: Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals; A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230. Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis, A. Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center, Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1. his detailed manual explains Paper Chromatography, a QC method for evaluating the radiochemical purity of currently used Tc-99m-labeled radiopharmaceuticals. Procedures are quick and easy to use, a simple quality control solution for any nuclear medicine department. FN: 11-029 1/11 150-000 Procedure Manual, Radiopharmaceutical QC 50 Biodex Medical Systems, Inc. • www.biodex.com